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It depends entirely on the composition of your bulk

Akroma, Vision of Ixidor ( Commander Legends ) This list wouldnt be complete without an Akroma, and though Angel of Fury and Angel of Wrath are a little outmoded these days, Vision of Ixidor offers a lot

There's also the obvious combo of infinite mana into Torment, ending the game immediately

Prevent all damage that would be dealt to you and permanents you control by sources with the chosen name

While this is fairly typical, in this article, Wizards also gave a brief blurb about each of the legends in Alchemy: Edge of Eternities

Creature - Soldier Spirit Color tag templates(None) Anthem (CTRL to add secondary) Counters Qty: 1 Price: $0.35 Favored Hoplite Heroic Whenever you cast a spell that targets this creature, put a +1/+1 counter on this creature and prevent all damage that would be dealt to it this turn